| 2010-11 DeSales Colts Basketball Schedule | |||||
| Date | Opponent | Location | Varsity | JV | Freshman |
| Nov. 30 | Manual | Away | 7:30 | 6:00 | 4:30 |
| Dec. 3 | CAL | Home | 7:30 | 6:00 | 4:30 |
| Dec. 7 | Lexington Catholic | Away | 7:45 | 6:15 | 4:45 |
| Dec. 10 | Butler | Home | 7:30 | 6:00 | 4:30 |
| Dec. 14 | Iroquois | Away | 7:30 | 6:00 | 4:30 |
| Dec. 15 | Valley | Home | 7:30 | 6:00 | 4:30 |
| Dec. 20-23 | Harrods Creek Classic | Mercer Co. | TBA | ||
| Dec. 26-30 | Fifth Third Holiday Classic | Lexington Catholic | TBA | ||
| Jan. 4 | St. Xavier | Home | 7:30 | 6:00 | 4:30 |
| Jan. 7 | Trinity | Away | 7:30 | 6:00 | 4:30 |
| Jan. 10-15 | Louisville Invitational Tournament | TBA | TBA | ||
| Jan. 18-22 | All ‘A’ Regional Tournament | DeSales | TBA | ||
| Jan. 28 | Bethlehem | Away | 7:30 | 6:00 | |
| Feb. 1 | Moore | Home | 7:30 | ||
| Feb. 2-6 | All ‘A’ State Tournament | EKU | TBA | ||
| Feb. TBA | Doss | Away | 7:30 | 6:00 | 4:30 |
| Feb. 8 | Bullitt Central (Senior Night) | Home | 7:30 | 6:00 | 4:30 |
| Feb. 11 | Holy Cross | Bellarmine | 8:00 | 6:15 | 5:00 |
| Feb. 15 | Fern Creek | Home | 7:30 | 6:00 | 4:30 |
| Feb. 18 | Bullitt East | Away | 7:30 | 6:00 | |